Resident Evil -- CODE: Veronica X picks up where the PlayStation's Resident Evil 2 left off, in Raccoon City. There, the Umbrella Corporation performed scientific experiments that went wrong. The result of their experiments was a virus that led to the creation of a huge number of zombies as well as a variety of other creatures bent on a path of death and destruction. As members of S.T.A.R.S. (Special Tactics and Rescue Squad), players did the best they could to stop the Umbrella Corp.'s madness, but ultimately Raccoon City and all of its inhabitants were wiped out.

Despite their failure in Raccoon City, Umbrella Corp. continues their experiments in their facilities located throughout the world as they attempt to create a powerful bio-weapon. Players first take on the role of Claire Redfield who had a starring role in Resident Evil 2.